I loaded up level 28 Prison of Elders for the first time, and ran it with Sarathil and a random. I think we wiped once. We got too excited with the scorch cannons and didn’t disarm the mines. No big deal, we grind it out no problem otherwise. We get to the end, drop into the treasure room, and I die from the fall (darn Warlock ankles!). The random opened the chest, which started the timer, and it ran out before I could make it back down and get any loot after respawn. I was pissed. It means I still have my key and I can run it on that level and get rewards, and I did get a rare ship (whoop de doo). So, time wasted is all.
The take aways:
Be careful with that end drop. If you take damage, take a second and heal it before you continue the fall.
Try to run that scenario with friends and people on chat, so as to not get screwed by someone opening a chest before everyone is ready.
Make sure you get good sleep before you decide to do any of these important scenarios. I was so tired even before we started playing, and that combined with the newness meant I was playing sub-par and making bad decisions.